Search results for "Engineering sciences. Technology"
showing 10 items of 32 documents
Linking photosynthesis and sun-induced fluorescence at sub-daily to seasonal scales
2018
Abstract Due to its close link to the photosynthetic process, sun-induced chlorophyll fluorescence (F) opens new possibilities to study dynamics of photosynthetic light reactions and to quantify CO2 assimilation rates. Although recent studies show that F is linearly related to gross primary production (GPP) on coarse spatial and temporal scales, it is argued that this relationship may be mainly driven by seasonal changes in absorbed photochemical active radiation (APAR) and less by the plant light use efficiency (LUE). In this work a high-resolution spectrometer was used to continuously measure red and far-red fluorescence and different reflectance indices within a sugar beet field during t…
Retinoic Acid affects Lung Adenocarcinoma growth by inducing differentiation via GATA6 activation and EGFR and Wnt inhibition
2016
AbstractA fundamental task in cancer research aims at the identification of new pharmacological therapies that can affect tumor growth. Differentiation therapy might exploit this function not only for hematological diseases, such as acute promyelocytic leukemia (APML) but also for epithelial tumors, including lung cancer. Here we show that Retinoic Acid (RA) arrests in vitro and in vivo the growth of Tyrosine Kinase Inhibitors (TKI) resistant Non Small Cell Lung Cancer (NSCLC). In particular, we found that RA induces G0/G1 cell cycle arrest in TKI resistant NSCLC cells and activates terminal differentiation programs by modulating the expression of GATA6, a key transcription factor involved …
Long-range vortex transfer in superconducting nanowires
2019
Under high-enough values of perpendicularly-applied magnetic feld and current, a type-II superconductor presents a fnite resistance caused by the vortex motion driven by the Lorentz force. To recover the dissipation-free conduction state, strategies for minimizing vortex motion have been intensely studied in the last decades. However, the non-local vortex motion, arising in areas depleted of current, has been scarcely investigated despite its potential application for logic devices. Here, we propose a route to transfer vortices carried by non-local motion through long distances (up to 10 micrometers) in 50nm-wide superconducting WC nanowires grown by Ga+ Focused Ion Beam Induced Deposition.…
Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway
2017
AbstractNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing osteoclasts and bone-forming osteoblasts activity is lost in bone metastasis, inducing osteoclastogenesis. In NSCLC, the epidermal growth factor receptor (EGFR) pathway is constitutively activated. EGFR binds Amphiregulin (AREG) that is overexpressed in several cancers such as colon, breast and lung. Its levels in plasma of NSCLC patients correlate with poor prognosis and AREG was recently …
Exosomal miRNA analysis in Non-Small Cell Lung Cancer (NSCLC) patients' plasma through qPCR : a feasible liquid biopsy tool
2016
Abstract: The discovery of alterations in the EGFR and ALK genes, amongst others, in NSCLC has driven the development of targeted-drug therapy using selective tyrosine kinase inhibitors (TKIs). To optimize the use of these TKIs, the discovery of new biomarkers for early detection and disease progression is mandatory. These plasma-isolated exosomes can be used as a non-invasive and repeatable way for the detection and followup of these biomarkers. One ml of plasma from 12 NSCLC patients, with different mutations and treatments (and 6 healthy donors as controls), were used as exosome sources. After RNAse treatment, in order to degrade circulating miRNAs, the exosomes were isolated with a comm…
Psychosocial factors associated with helmet use by adult cyclists
2019
Abstract: This study examines beliefs about helmet use in adult cyclists from 17 countries participating in the COST Action TU1101 Project (Helmet Optimization in Europe – HOPE). A total of 5797 respondents were included in the analysis after applying eligibility criteria and data cleaning. Cyclists' beliefs were assessed by 25 items using a 7-point Likert scale. These items were factor analyzed resulting in a four-factor solution (Factor 1: Perceived Benefits and Risk Reduction, Factor 2: Perceived Disadvantages and Barriers to Helmet Use, Factor 3: Perception of Group Norms, and Factor 4: Situation-Dependence of Helmet Use). Results show that both beliefs and helmet wearing behavior diffe…
Bidirectional sun-induced chlorophyll fluorescence emission is influenced by leaf structure and light scattering properties : a bottom-up approach
2015
Abstract Sun-induced chlorophyll fluorescence (SIF) at leaf level is emitted in both upward and downward directions in the red and far-red part of the spectrum (650–850 nm) when a leaf is illuminated from the upper leaf surface. Hence, total SIF is represented by the sum of the upward and downward emission components. Nevertheless, the downward component of leaf SIF is often not considered despite that downward fluorescence yield (↓FY) can amount up to 40% of the total fluorescence yield (FYtot). Downward SIF is mainly emitted in the far-red, since this part of fluoresced light is highly scattered within leaves, unlike red Chl fluorescence, which is mostly reabsorbed. While total FY can be …
Experimental Investigation on Water Loss and Stiffness of CBTM Using Different RA Sources
2021
Cold recycling of reclaimed asphalt (RA) is a promising technique to build or to maintain roads, combining performance and environmental advantages. Although this technique has been extensively used worldwide, there is no unique and internationally-shared method to characterize cold recycled mixtures. The previous work of the RILEM TC 237-SIB TG6 successfully attempted to characterize different RA sources with both traditional parameters (gradation, bitumen content and geometrical properties) and non-conventional properties (fragmentation and strength testing). The current RILEM TC 264-RAP TG1 mainly focuses on the influence of different RA sources on physical and mechanical characteristics…
Optical remote sensing and the retrieval of terrestrial vegetation bio-geophysical properties – A review
2015
Abstract: Forthcoming superspectral satellite missions dedicated to land monitoring, as well as planned imaging spectrometers, will unleash an unprecedented data stream. The processing requirements for such large data streams involve processing techniques enabling the spatio-temporally explicit quantification of vegetation properties. Typically retrieval must be accurate, robust and fast. Hence, there is a strict requirement to identify next-generation bio-geophysical variable retrieval algorithms which can be molded into an operational processing chain. This paper offers a review of state-of-the-art retrieval methods for quantitative terrestrial bio-geophysical variable extraction using op…
Engineering multi-agent systems: State of affairs and the road ahead
2019
International audience; The continuous integration of software-intensive systems together with the ever-increasing computing power offer a breeding ground for intelligent agents and multi-agent systems (MAS) more than ever before. Over the past two decades, a wide variety of languages, models, techniques and methodologies have been proposed to engineer agents and MAS. Despite this substantial body of knowledge and expertise, the systematic engineering of large-scale and open MAS still poses many challenges. Researchers and engineers still face fundamental questions regarding theories, architectures, languages, processes, and platforms for designing, implementing, running, maintaining, and e…